GLP-1 receptor
Records checked
Compiled and citation-checked by GLP-1 Receptor Agonists editorial desk
Qualified clinical review None on record
12 of the 17 compounds in scope are recorded as acting at the GLP-1 receptor. 7 of them record it as their only target; the rest carry a multi-receptor profile.
Definition
The glucagon-like peptide-1 receptor is the receptor targeted by the incretin receptor agonist class. A 2024 review in Signal Transduction and Targeted Therapy surveys its signalling mechanisms and advances in agents acting on it.[1]
Also written as glucagon-like peptide-1 receptor, GLP1R.
Recorded on the compound records as: GLP-1 receptor.
Compounds in scope recorded at this target
| Compound | Class | Other targets recorded | Targets | Records | Human trial model | Phase 3 | Index state |
|---|---|---|---|---|---|---|---|
| Dulaglutide | Incretin receptor agonists | None recorded | 1 | 12 | 11 | 3 | Withheld |
| Exenatide | Incretin receptor agonists | None recorded | 1 | 12 | 12 | 3 | Withheld |
| GLP-1 | Incretin receptor agonists | None recorded | 1 | 12 | 1 | 0 | Withheld |
| Liraglutide | Incretin receptor agonists | None recorded | 1 | 12 | 11 | 4 | Withheld |
| Lixisenatide | Incretin receptor agonists | None recorded | 1 | 12 | 9 | 1 | Withheld |
| Maridebart cafraglutide | Incretin receptor agonists | GIP receptor | 2 | 5 | 2 | 0 | Withheld |
| Mazdutide | Incretin receptor agonists | Glucagon receptor | 2 | 12 | 6 | 4 | Withheld |
| Orforglipron | Incretin receptor agonists | None recorded | 1 | 12 | 8 | 5 | Withheld |
| Retatrutide | Incretin receptor agonists | GIP receptor, Glucagon receptor | 3 | 12 | 3 | 1 | Withheld |
| Semaglutide | Incretin receptor agonists | None recorded | 1 | 12 | 10 | 3 | Withheld |
| Survodutide | Incretin receptor agonists | Glucagon receptor | 2 | 12 | 6 | 4 | Withheld |
| Tirzepatide | Incretin receptor agonists | GIP receptor | 2 | 12 | 10 | 7 | Withheld |
Record counts are of records this corpus carries, not of the literature. A larger count reflects how long and how heavily a compound has been indexed. It is not a measure of anything about the compound, and the rows are in alphabetical order so the table cannot be read as a ranking.
What else these compounds are recorded at
- GIP receptor: 3 of the 12 also recorded at the GIP receptor
- Glucagon receptor: 3 of the 12 also recorded at the Glucagon receptor
Where this page sits
- Every receptor target in scope
- The glossary of receptor terms
- Coverage by endpoint, across all compounds in scope
Sources
- Glucagon-like peptide-1 receptor: mechanisms and advances in therapy. Signal Transduct Target Ther (2024). pmid:39289339